|
KMID : 0370220100540050392
|
|
Yakhak Hoeji
2010 Volume.54 No. 5 p.392 ~ p.397
|
|
|
The Synergistic Effect of Additional Ethanol Exposure on Quercetin-induced Vasorelaxation in a Vasoconstrictor-dependent Manner
|
|
Jin Young-Bea
Je Hyun-Dong
|
|
|
Abstract
|
|
|
|
The aim of present study was to investigate the possible influence and related mechanism of additional alcohol on the flavonoid- induced arterial relaxation. Agonist-induced vascular smooth muscle contractions involve the activation of thick or thin filament pathway. However, there are no reports addressing the question whether this pathway is involved in quercetin-induced relaxation cotreated with alcohol in rat aortae contracted with phorbol ester, fluoride or thromboxane mimetic U-46619. We hypothesized that cotreated alcohol plays a role in vascular relaxation evoked by quercetin in rat aortae. Endothelium-denuded arterial rings from male Sprague-Dawley rats were used and isometric contractions were recorded using a computerized data acquisition system. Quercetin inhibited phorbol ester, fluoride or thromboxane -induced contraction regardless of endothelial function. However, alcohol didn’t decrease any agonist-induced contraction. Interestingly, only in thromboxane -induced contraction, synergistic results were observed in aortae denuded and cotreated with quercetin and alcohol suggesting that additional pathways different from antioxidation or endothelial nitric oxide synthesis might be involved in the vasorelaxation. In conclusion, in the agonists-contracted rat aortae, quercetin and alcohol together showed synergistic response regardless of endothelial function in an agonist-dependent manner.
|
|
|
KEYWORD
|
|
|
alcohol, fluoride, phorbol ester, quercetin, Rho-kinase, thromboxane mimetic, vasoconstriction
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|